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Skunks use their anal glands to spray a foul-smelling and sticky fluid as a defense against predators. Textbook of Veterinary Internal Medicine 4th ed. Initial treatment usually involves the manual expression of the anal sacs, most often by a veterinary professional. The glands are at varying depths in the anal canal wall, some between the layers of the internal and external sphincter the intersphincteric plane. Potential complications include fecal incontinence especially when both glands are removed , tenesmus from stricture or scar formation, and persistent draining fistulae.

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Opossums use their anal glands when they " play possum ".

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Anal gland

Note that opossums are not members of the carnivora, and that their anal sacs differ from those of dogs and their relatives. This is usually done in the case of recurrent infection or because of the presence of an anal sac adenocarcinoma , a malignant tumor. Textbook of Veterinary Internal Medicine 4th ed. Dogs and cats primarily use their anal gland secretions to mark their territory, and generally will secrete small amounts of fluid every time they defecate. Sebaceous glands within the lining secrete a liquid that is used for identification of members within a species. Anal sac fluid varies from yellow to tan or brown in color. Anal sacs may be removed surgically in a procedure known as anal sacculectomy.

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